Duodenal levodopa infusion for advanced Parkinson's disease: 12‐month treatment outcome
Identifieur interne : 001066 ( Main/Exploration ); précédent : 001065; suivant : 001067Duodenal levodopa infusion for advanced Parkinson's disease: 12‐month treatment outcome
Auteurs : Angelo Antonini [Italie] ; Ioannis U. Isaias [Italie] ; Margherita Canesi [Italie] ; Maurizio Zibetti [Italie] ; Francesca Mancini [Italie] ; Luigi Manfredi [Italie] ; Marco Dal Fante [Italie] ; Leonardo Lopiano [Italie] ; Gianni Pezzoli [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-06-15.
English descriptors
- KwdEn :
Abstract
We assessed prospectively clinical and quality of life changes in 9 patients with Parkinson's disease (PD; H&Y ≥ 3) with severe motor fluctuations and dyskinesia who started continuous daily levodopa duodenal infusion through percutaneous endoscopic gastrostomy. Seven patients completed the follow‐up period. Duration of “off” periods and time with disabling dyskinesia shortened significantly in all patients (P < 0.01). Total daily dose of levodopa infused did not differ from baseline equivalents. There were significant improvements in UPDRS‐II (activities of daily living) and ‐IV (motor complications) in the “on” condition (P < 0.02), and in four PDQ‐39 domains (mobility, activities of daily living, stigma, bodily discomfort; P < 0.05). Two patients withdrew for adverse events. Our results demonstrate that a satisfactory therapeutic window can be achieved and maintained for several months in advanced PD patients. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21500
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Duodenal levodopa infusion for advanced Parkinson's disease: 12‐month treatment outcome</title><author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name></author><author><name sortKey="Isaias, Ioannis U" sort="Isaias, Ioannis U" uniqKey="Isaias I" first="Ioannis U." last="Isaias">Ioannis U. Isaias</name></author><author><name sortKey="Canesi, Margherita" sort="Canesi, Margherita" uniqKey="Canesi M" first="Margherita" last="Canesi">Margherita Canesi</name></author><author><name sortKey="Zibetti, Maurizio" sort="Zibetti, Maurizio" uniqKey="Zibetti M" first="Maurizio" last="Zibetti">Maurizio Zibetti</name></author><author><name sortKey="Mancini, Francesca" sort="Mancini, Francesca" uniqKey="Mancini F" first="Francesca" last="Mancini">Francesca Mancini</name></author><author><name sortKey="Manfredi, Luigi" sort="Manfredi, Luigi" uniqKey="Manfredi L" first="Luigi" last="Manfredi">Luigi Manfredi</name></author><author><name sortKey="Dal Fante, Marco" sort="Dal Fante, Marco" uniqKey="Dal Fante M" first="Marco" last="Dal Fante">Marco Dal Fante</name></author><author><name sortKey="Lopiano, Leonardo" sort="Lopiano, Leonardo" uniqKey="Lopiano L" first="Leonardo" last="Lopiano">Leonardo Lopiano</name></author><author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DBA29EB67ABFF098920EF93653FEED96767CA3FD</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/mds.21500</idno><idno type="url">https://api.istex.fr/document/DBA29EB67ABFF098920EF93653FEED96767CA3FD/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001522</idno><idno type="wicri:Area/Main/Curation">001297</idno><idno type="wicri:Area/Main/Exploration">001066</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Duodenal levodopa infusion for advanced Parkinson's disease: 12‐month treatment outcome</title><author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Isaias, Ioannis U" sort="Isaias, Ioannis U" uniqKey="Isaias I" first="Ioannis U." last="Isaias">Ioannis U. Isaias</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Milano Bicocca, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Canesi, Margherita" sort="Canesi, Margherita" uniqKey="Canesi M" first="Margherita" last="Canesi">Margherita Canesi</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Zibetti, Maurizio" sort="Zibetti, Maurizio" uniqKey="Zibetti M" first="Maurizio" last="Zibetti">Maurizio Zibetti</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Torino, Torino</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Mancini, Francesca" sort="Mancini, Francesca" uniqKey="Mancini F" first="Francesca" last="Mancini">Francesca Mancini</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Department Neurology and Gastroenterology, Hospital San Pio X, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Manfredi, Luigi" sort="Manfredi, Luigi" uniqKey="Manfredi L" first="Luigi" last="Manfredi">Luigi Manfredi</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Department Neurology and Gastroenterology, Hospital San Pio X, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Dal Fante, Marco" sort="Dal Fante, Marco" uniqKey="Dal Fante M" first="Marco" last="Dal Fante">Marco Dal Fante</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Department Neurology and Gastroenterology, Hospital San Pio X, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Lopiano, Leonardo" sort="Lopiano, Leonardo" uniqKey="Lopiano L" first="Leonardo" last="Lopiano">Leonardo Lopiano</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, University of Torino, Torino</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-06-15">2007-06-15</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1145">1145</biblScope><biblScope unit="page" to="1149">1149</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">DBA29EB67ABFF098920EF93653FEED96767CA3FD</idno><idno type="DOI">10.1002/mds.21500</idno><idno type="ArticleID">MDS21500</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>carbidopa</term><term>continuous infusion</term><term>duodenal administration</term><term>levodopa</term><term>motor complications.</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We assessed prospectively clinical and quality of life changes in 9 patients with Parkinson's disease (PD; H&Y ≥ 3) with severe motor fluctuations and dyskinesia who started continuous daily levodopa duodenal infusion through percutaneous endoscopic gastrostomy. Seven patients completed the follow‐up period. Duration of “off” periods and time with disabling dyskinesia shortened significantly in all patients (P < 0.01). Total daily dose of levodopa infused did not differ from baseline equivalents. There were significant improvements in UPDRS‐II (activities of daily living) and ‐IV (motor complications) in the “on” condition (P < 0.02), and in four PDQ‐39 domains (mobility, activities of daily living, stigma, bodily discomfort; P < 0.05). Two patients withdrew for adverse events. Our results demonstrate that a satisfactory therapeutic window can be achieved and maintained for several months in advanced PD patients. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li><li>Piémont</li></region><settlement><li>Milan</li><li>Turin</li></settlement></list><tree><country name="Italie"><region name="Lombardie"><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name></region><name sortKey="Canesi, Margherita" sort="Canesi, Margherita" uniqKey="Canesi M" first="Margherita" last="Canesi">Margherita Canesi</name><name sortKey="Dal Fante, Marco" sort="Dal Fante, Marco" uniqKey="Dal Fante M" first="Marco" last="Dal Fante">Marco Dal Fante</name><name sortKey="Isaias, Ioannis U" sort="Isaias, Ioannis U" uniqKey="Isaias I" first="Ioannis U." last="Isaias">Ioannis U. Isaias</name><name sortKey="Isaias, Ioannis U" sort="Isaias, Ioannis U" uniqKey="Isaias I" first="Ioannis U." last="Isaias">Ioannis U. Isaias</name><name sortKey="Lopiano, Leonardo" sort="Lopiano, Leonardo" uniqKey="Lopiano L" first="Leonardo" last="Lopiano">Leonardo Lopiano</name><name sortKey="Mancini, Francesca" sort="Mancini, Francesca" uniqKey="Mancini F" first="Francesca" last="Mancini">Francesca Mancini</name><name sortKey="Manfredi, Luigi" sort="Manfredi, Luigi" uniqKey="Manfredi L" first="Luigi" last="Manfredi">Luigi Manfredi</name><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name><name sortKey="Zibetti, Maurizio" sort="Zibetti, Maurizio" uniqKey="Zibetti M" first="Maurizio" last="Zibetti">Maurizio Zibetti</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001066 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001066 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:DBA29EB67ABFF098920EF93653FEED96767CA3FD
|texte= Duodenal levodopa infusion for advanced Parkinson's disease: 12‐month treatment outcome
}}
| This area was generated with Dilib version V0.6.23. |  |